La castración inmunológica de los cerdos machos: estado actual

  • Roberto Basulto Baker Centro de Ingeniería Genética y Biotecnología (CIGB), CP 70100, Apdo. 387, Camagüey, Cuba. https://orcid.org/0000-0002-1966-120X

Resumen

Antecedentes: La ceba de los cerdos enteros tiene las desventajas del olor sexual en la carne y los problemas de bienestar por el comportamiento agresivo y la monta. La castración quirúrgica reduce estos comportamientos y facilita el manejo, incrementa el peso, mejora las cualidades de la carne y la libera de olor y sabor a verraco. Sin embargo, es una práctica polémica ya que causa heridas, dolor, estrés, somete a los animales a riesgos por infecciones, inflamaciones crónicas y complicaciones post-operatorias. Objetivo. Examinar el estado actual de la inmunocastración como alternativa viable a la castración quirúrgica de los cerdos machos.

Desarrollo: La inmunocastración es una opción segura, comercialmente factible, amigable con el bienestar animal y viable para la producción sostenible de cerdos, pues favorece la calidad de la carne, la rentabilidad económica y la protección del medio ambiente. Sin embargo, su aplicación es insuficiente, excepto en Australia, Brasil y Nueva Zelanda y predomina la castración quirúrgica en la mayoría de los países.

Conclusiones: La inmunocastración es una tecnología relativamente reciente, su aceptación, introducción y extensión pueden generar incertidumbres y resistencia por parte de los diferentes actores de la cadena de producción porcina. Esta práctica demanda de los productores mayor disciplina tecnológica para obtener los beneficios esperados. La extensión de su uso requiere su aprobación por todas las partes interesadas que integran la cadena de producción, además, mercados que demanden la carne de estos cerdos y de actores dispuestos a comercializarla.

Palabras claves: cerdos, GnRH, inmunocastración, vacunas peptídicas (Fuente: MeSH)

Citas

Aluwé, M., Tuyttens, F.A.M., & Millet, S. (2015a). Field experience with surgical castration with anaesthesia, analgesia, immunocastration and production of entire male pigs: Performance, carcass traits and boar taint prevalence. Animal, 9(3), 500-508. https://doi.org/10.1017/S1751731114002894

Aluwé, M., Vanhonacker, F., Millet, S., & Tuyttens, A.M. (2015b). Influence of hands-on experience on pig farmers' attitude towards alternatives for surgical castration of male piglets. Research in Veterinary Science, 103, 80-86. https://doi.org/10.1016/j.rvsc.2015.09.019

Backus, G., Higuera, M., Juul, N., Nalon, E., & de Briyne, N. (2018). Second Progress Report 2015–2017 on the European Declaration on Alternatives to Surgical Castration of Pigs. https://www.boarsontheway.com/wp-content/uploads/2018/08/Second-progress-report-2015-2017-final-1.pdf [Consultado: 20 de abril de 2020].

Bonneau, M. (2010). Accessory sex glands as a tool to measure the efficacy of immunocastration in male pigs. Animal, 4(6), 930-932. https://doi.org/10.1017/S1751731110000091

Bonneau, M., & Weiler, U. (2019). Pros and Cons of Alternatives to Piglet Castration: Welfare, Boar Taint, and Other Meat Quality Traits. Animals, 9(11), 884, 1-12. https://doi.org/10.3390/ani9110884

Buhr, B., Tonsor, G., Zering, K., DiPietre, D., Cowles, B., & de Moraes, P.J.U. (2013). Comprehensive economic analysis of Improvest® adoption by the US pork industry. Zoetis Inc. (june 2013). Technical update. https://www.zoetisus.com/products/pork/improvest/pdf/ImprovestEconomicTechnicalBulletin.pdf [Consultado: 29 de mayo de 2019].

Čandek-Potokar, M., Prevolnik, M., & Škrlep, M. (2014). Testes Weight is not a reliable tool for discriminating immunocastrates from entire males. Paper presented to International Symposium on Animal Science, Belgrade-Zemun, 23-25 September. https://www.researchgate.net/profile/Marjeta_Candek-Potokar/publication/273767098_TESTES_WEIGHT_IS_NOT_A_RELIABLE_TOOL_FOR_DISCRIMINATING_IMMUNOCASTRATES_FROM_ENTIRE_MALES/links/550bd9a50cf265693cefaa80/TESTES-WEIGHT-IS-NOT-A-RELIABLE-TOOL-FOR-DISCRIMINATING-IMMUNOCASTRATES-FROM-ENTIRE-MALES.pdf

Čandek-Potokar, M., Škrlep, M., & Batorek Lukac, N. (2015). Raising entire males or immunocastrates-outlook on meat quality. Procedia Food Science 5, 30-33. https://doi.org/10.1016/j.profoo.2015.09.008

Čandek-Potokar, M., Škrlep, M., & Zamaratskaia, G. (2017). Immunocastration as alternative to surgical castration in pigs. Theriogenology, 6, 109-126. https://dx.doi.org/10.5772/intechopen.68650

Decreto No. 9.013, de 29 de março de 2017, Brasilia, Brasil; 2017. http://www.planalto.gov.br/ccivil_03/_Ato2015-2018/2017/Decreto/D9013.htm#art541 [Consultado: 30 de julio de 2020].

D’Souza, D.N., Hewitt, R.J.E., & van Barneveld, R.J. (2018). Pork production with entire males and immunocastrates in Australia. https://meetings.eaap.org/wp-content/uploads/2018/Session7/S07_01_DSouza.pdf [Consultado: 29 de mayo de 2019].

De Briyne, N., Berg, C., Blaha, T., & Temple, D. (2016). Pig castration: will the EU manage to ban pig castration by 2018?. Porcine Health Management, 2(1), 29, 1-11. https://doi.10.1186/s40813-016-0046-x

De Moraes, P.J., Allison, J., Robinson, J.A., Baldo, G.L., Boeri, F., & Borla, P. (2013). Life cycle assessment (LCA) and environmental product declaration (EPD) of an immunological product for boar taint control in male pigs. Journal of Environmental Assessment Policy and Management, 15(01), 1350001. https://doi.org/10.1142/S1464333213500014

Di Pasquale, J., Nannoni, E., Sardi, L., Rubini, G., Salvatore, R., Bartoli, L., Adinolfi F., & Martelli, G. (2019). Towards the Abandonment of Surgical Castration in Pigs: How is Immunocastration Perceived by Italian Consumers?. Animals, 9(5), 198. https://doi.org/10.3390/ani9050198

Dunshea, F.R., Allison, J.R.D., Bertram, M., Boler, D.D., Brossard, L., Campbell, R., ... & Ferguson, N. (2013). The effect of immunization against GnRF on nutrient requirements of male pigs: A review. Animal, 7(11), 1769-1778. https://doi.10.1017/S1751731113001407

Einarsson, S., Brunius, C., Wallgren, M., Lundström, K., Andersson, K., Zamaratskaia, G., & Rodriguez-Martinez, H. (2011). Effects of early vaccination with Improvac® on the development and function of reproductive organs of male pigs. Animal Reproduction Science, 127(1-2), 50-5. https://doi.org/10.1016/j.anireprosci.2011.06.006

EC (European Commission). (2010). European Declaration on Alternatives to Surgical Castration of Pigs. https://ec.europa.eu/food/sites/food/files/animals/docs/aw_prac_farm_pigs_castalt_declaration_en.pdf [Consultado: 30 de julio de 2019].

EC (European Commission). (2019). Establishing Best Practices on the Production, the Processing and the Marketing of Meat from Uncastrated Pigs or Pigs Vaccinated Against Boar Taint (Immunocastrated). https://ec.europa.eu/food/sites/food/files/animals/docs/aw_prac_farm_pigs_cast-alt_establishing-best-practices.pdf Consultado: 11 de mayo del 2020.

EMA (European Medicines Agency). (2009). EPAR Summary for the Public. https://www.ema.europa.eu/en/documents/overview/Improvac-epar-summary-public_en.pdf Consultado: 2 de abril de 2020.

EMA (European Medicines Agency). (2010). EPAR-Scientific Discussion. https://www.ema.europa.eu/en/documents/scientific-discussion/Improvac-epar-scientific-discussion_en.pdf [Consultado: 9 de abril de 2020].

FDA (Food and Drug Administration). (2011). Implantation or Injectable Dosage Form New Animal Drugs; Gonadotropin Releasing Factor-Diphtheria Toxoid Conjugate. https://www.federalregister.gov/documents/2011/05/13/2011-11762/implantation-or-injectable-dosage-form-new-animal-drugs-gonadotropin-releasing-factor-diphtheria [Consultado: 6 de julio de 2020].

Giersing, M., Ladewig, J., & Forkman, B. (2006). Animal welfare aspects of preventing boar taint. Acta Veterinaria Scandinavica, 48(S1), 1-3. https://doi.10.1186/1751-0147-48-S1-S3

Gupta, S.K., & Minhas, V. (2017). Wildlife population management: are contraceptive vaccines a feasible proposition?. Frontiers in bioscience (Scholar edition), 9, 357-374. https://doi.10.2741/s492

Heegaard, P.M., Fang, Y., & Jungersen, G. (2016). Novel adjuvants and immunomodulators for veterinary vaccines. In Vaccine Technologies for Veterinary Viral Diseases (pp. 63-82). Humana Press, New York, NY. https://doi.10.1007/978-1-4939-3008-1_5

Kallas, Z., Gil, J.M., Panella-Riera, N., Blanch, M., Font-i-Furnols, M., Chevillon, P., ... & Oliver, M.A. (2013). Effect of tasting and information on consumer opinion about pig castration. Meat Science, 95(2), 242-249. https://doi.org/10.1016/j.meatsci.2013.05.011

Karaconji, B., Lloyd, B., Campbell, N., Meaney, D.F., & Ahern, T. (2015). Effect of an anti-gonadotropin-releasing factor vaccine on sexual and aggressive behaviour in male pigs during the finishing period under Australian field conditions. Australian Veterinary Journal, 93(4), 121-123. https://doi.org/10.1111/avj.12307

Kress, K., Millet, S., Labussière, É., Weiler, U., & Stefanski, V. (2019). Sustainability of pork production with immunocastration in Europe. Sustainability, 11(12), 3335. https://doi.org/10.3390/su11123335

Kress, K., Weiler, U., Schmucker, S., Čandek-Potokar, M., Vrecl, M., Fazarinc, G., ... & Stefanski, V. (2020). Influence of Housing Conditions on Reliability of Immunocastration and Consequences for Growth Performance of Male Pigs. Animals, 10(1), 27. https://doi.org/10.3390/ani10010027

Lundström, K., Matthews, K.R., & Haugen, J.E. (2009). Pig meat quality from entire males. Animal, 3(11), 1497-1507. https://doi.org/10.1017/S1751731109990693

Mancini, M.C., Menozzi, D., & Arfini, F. (2017). Immunocastration: Economic implications for the pork supply chain and consumer perception. An assessment of existing research. Livestock Science, 203, 10-20. https://doi.org/10.1016/j.livsci.2017.06.012

Matsuo, H., Baba, Y., Nair, R.M., Arimura, A., & Schally, A.V. (1971). Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence. Biochemical and Biophysical Research Communications, 43(6), 1334-1339. https://doi.org/10.1016/S0006-291X(71)80019-0

McNamara, M.K. (2014). U.S. Patent No. 8,741,303. Washington, DC: U.S. Patent and Trademark Office.

Millar, R.P., Pawson, A.J., Morgan, K., Rissman, E.F., & Lu, Z.L. (2008). Diversity of actions of GnRHs mediated by ligand-induced selective signaling. Frontiers in Neuroendocrinology, 29(1), 17-35. https://doi.org/10.1016/j.yfrne.2007.06.002

Morales, J., Dereu, A., Manso, A., de Frutos, L., Piñeiro, C., Manzanilla, E.G., & Wuyts, N. (2017). Surgical castration with pain relief affects the health and productive performance of pigs in the suckling period. Porcine Health Management, 3(18), 1-6. https://doi.org/10.1186/s40813-017-0066-1

Morgan, L., Itin-Shwartz, B., Koren, L., Meyer, J.S. Matas, D., Younis, A., Novak, S., Weizmann, N., Rapaic, O., Ahmad, W.A., Klement, E., & Raz, T. (2019). Physiological and economic benefits of abandoning invasive surgical procedures and enhancing animal welfare in swine production. Scientific Reports, 9:16093, 1-14. https://doi.org/10.1038/s41598-019-52677-6

Nautrup, B.P., Vlaenderen, I.V., Aldaz, A., & Mah, C.K. (2018). The effect of immunization against gonadotropin-releasing factor on growth performance, carcass characteristics and boar taint relevant to pig producers and the pork packing industry: A meta-analysis. Research in Veterinary Science, 119, 182-195. https://doi.org/10.1016/j.rvsc.2018.06.002

OIE (Organización Mundial de Sanidad Animal). (2019). Código Sanitario para los Animales Terrestres. https://www.oie.int/es/normas/codigo-terrestre/ [Consultado: 06 de enero de 2020].

Prunier, A., Mournier, A.M., & Hay, M. (2005). Effects of castration, tooth resection, or tail docking on plasma metabolite and stress hormones in young pigs. Journal of Animal Science, 83(1), 216-222. https://doi.org/10.2527/2005.831216x

Reiter, S., Zöls, S., Ritzmann, M., Stefanski, V., & Weiler, U. (2017). Penile injuries in immunocastrated and entire male pigs of one fattening farm. Animals, 7(9), 1-7. https://doi.org/10.3390/ani7090071

Rosenfield, D., & Pizzutto, C. (2018). Wildlife population control - reproductive physiology under the influence of contraceptive methods in mammalian wildlife, with emphasis on immunocontraception: the best choice? A literature review. Brazilian Journal of Veterinary Research and Animal Science, 55(1), 1-16. https://doi.org/10.11606/issn.1678-4456.bjvras.2018.129431

Rueff, L., Mellencamp, M.A., & Pantoja, L.G. (2019). Performance of immunologically castrated pigs at a commercial demonstration farm over 3.5 years. Journal of Swine Health and Production, 27(6), 322-328.

Rydhmer, L., Zamaratskaia, G., Andersson, H.K., Algers, Bo, Guillemet, R., & Lundström, K. (2006). Aggressive and sexual behavior of growing and finishing pigs reared in groups, without castration. Acta Agriculturae Scandinavica, Section A: Animal Science, 56(2), 109-119. https://doi.org/10.1080/09064700601079527

Rydhmer, L., Lundström, K., & Andersson, K. (2010). Immunocastration reduces aggressive and sexual behaviour in male pigs. Animal, 4(6), 965-972. https://doi.org/10.1017/S175173111000011X

Škrlep, M., Šegula, B., Zajec, M., Kastelic, M., Košorok, S., Fazarinc, G., & Čandek-Potokar, M. (2010). Effect of immunocastration (Improvac®) in fattening pigs I: growth performance, reproductive organs and malodorous compounds. Slovenian Veterinary Research, 47(2), 57-64.

Škrlep, M., Batorek-Lukač, N., Prevolnik-Povše, M., & Čandek-Potokar, M. (2014). Theoretical and practical aspects of immunocastration. Stočarstvo: Časopis za unapređenje stočarstva, 68(2), 39-49.

Sládek, Z., Prudíková, M., Knoll, A., Kulich, P., Steinhauserová, I., & Bořilová, G. (2018). Effect of early immunocastration on testicular histology in pigs. Veterinarni Medicina, 63(1), 18-27.

Stupka, R., Čítek, J., Vehovský, K., Zadinová, K., Okrouhlá, M., Urbanová, D., & Stádník, L. (2017). Effects of immunocastration on growth performance, body composition, meat quality, and boar taint. Czech Journal of Animal Science, 62(6), 249-58.

Vanhonacker, F., & Verbeke, W. (2011). Consumer response to the possible use of a vaccine method to control boar taint v. physical piglet castration with anaesthesia: a quantitative study in four European countries. Animal, 5(7), 1107-1118. https://doi.org/10.1017/S1751731111000139

Von Borell, E., Baumgartner, J., Giersing, M., Jäggin, N., Prunier, A., Tuyttens, F.A.M., & Edwards, S.A. (2009). Animal welfare implications of surgical castration and its alternatives in pigs. Animal, 3(11), 1488-1496. https://doi.org/10.1017/S1751731109004728

Weiler, U., & Bonneau, M. (2019). Why it is so difficult to end surgical castration of boars in Europe: Pros and cons of alternatives to piglet castration. In IOP Conference Series: Earth and Environmental Science (Vol. 333, No. 1, p. 012001). IOP Publishing. https://doi.org/10.1088/1755-1315/333/1/012001

Whitlock, K., Postlethwait, J., & Ewer, J. (2019). Neuroendocrinology of reproduction: Is gonadotropin-releasing hormone (GnRH) dispensable?. Frontiers in Neuroendocrinology, 53, 100738, 1-12. https://doi.org/10.1016/j.yfrne.2019.02.002

Zamaratskaia, G., Andersson, H.K., Chen, G., Andersson, K., Madej, A., & Lundström, K. (2008). Effect of a Gonadotropin‐releasing Hormone Vaccine (ImprovacTM) on Steroid Hormones, Boar Taint Compounds and Performance in Entire Male Pigs. Reproduction in Domestic Animals, 43(3), 351-359. https://doi.org/10.1111/j.1439-0531.2007.00914.x

Zamaratskaia, G., & Rasmussen, M.K. (2015). Immunocastration of male pigs - situation today. Procedia Food Science, 5(2), 324-327. https://doi.org/10.1016/j.profoo.2015.09.064

Zoels, S., Reiter, S., Ritzmann, M., Weiß, C., Numberger, J., Schütz, A., ... & Weiler, U. (2020). Influences of Immunocastration on Endocrine Parameters, Growth Performance and Carcass Quality, as Well as on Boar Taint and Penile Injuries. Animals, 10(2), 346. https://doi.org/10.3390/ani10020346

Publicado
2020-08-05
Cómo citar
Basulto Baker, R. (2020). La castración inmunológica de los cerdos machos: estado actual. Revista De Producción Animal, 32(3). Recuperado a partir de https://revistas.reduc.edu.cu/index.php/rpa/article/view/e3527